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Wozniak et al., 2016)

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In this longitudinal study, they determined that at baseline the expression of Nrf2 and Nrf2-related genes (heme oxygenase (HO)-1 and glutamate-cysteine ligase catalytic (GCLC) subunit) in PBMCS was significantly increased in COPD compared to no-COPD subjects, whereas at the follow-up (49.7 6.9 months) the expression was significantly decreased in COPD which worsened over that time, while no changes were observed in no-COPD subjects

380 For example, the PADs (Section 4), microarrays, or chemical noses (Section 5) within a single test strip is an example of spatial multiplexing, where combinational colors encode different analytes in multiple detection spots, addressing the need for comprehensive diagnostic testing

At the root of this deterioration of physical fitness is damage to mitochondria, the cells powerhouse, and, ultimately, cells caused by oxidative stress the buildup of harmful, oxygen-containing molecules and lack of antioxidants