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It has been demonstrated that GSH depleted astrocytes lose their neuroprotective roles, leading to neuronal toxicity and a consequent reduction in cell viability (Pizzurro et al., 2014a,b)

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Premedication and Concomitant Agents to Mitigate Toxicity: Vitamin supplementation: Start folic acid (400 to 1000 mcg orally once a day) 7 days before the first dose of this drug and continue until 21 days after the last dose of this drug

We need to understand that this issue does not affect each individual

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