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cyclodextrin complexation, nano-formulations, prodrugs) which take into account the existing solubility issues and absorption issues respectively, while utilizing current techniques like LC-MS/MS-high resolution mass spectrometry (HRMS) to systematically determine the context of the in vivo metabolism of caudatin and define it's metabolites ( 5 Safety profile In vitro and in vivo studies on the toxicity of caudatin have shown that it exhibits a relatively low toxicity profile in terms of its therapeutic efficacy (Figure 6)