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This timeframe assumes proper reconstitution technique, appropriate diluent selection, and consistent cold storage without temperature excursions

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[64] Such an activatable antibody construct may be an antibody or an antigen binding fragment thereof that typically comprises (i) at least two binding domains each comprising a heavy chain amino acid sequence and a light chain amino acid sequence, (ii) a masking moiety that inhibits the binding of each binding domain in an uncleaved state to the respective binding partner such as a target cell surface, and (iii) a cleavable moiety positioned between (i) and (ii), wherein the cleavable moiety is a polypeptide that functions as a substrate e.g

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice