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(2013) characterized the role of NNMT in cancer cell metabolism, demonstrating that NNMT activity creates a metabolic sink for SAM

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The mechanistic literature leans against a classic tolerance effect, not toward it

The antifungal agent ketoconazole has a dual role in hair loss compounding: it reduces Malassezia overgrowth on the scalp (a contributor to follicular inflammation and seborrheic dermatitis) and has demonstrated weak anti-androgenic properties