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AaRSs and translational quality control Faithful translation of the genetic message is paramount for the accurate synthesis of proteins and to prevent the introduction of mutations often associated with loss of function and disease

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It has a wide spectrum of metabolic effects, including induction of apoptosis via ROS production and cytochrome c release (17), inhibition of NADH oxidation (18), and loss of GSH (19)

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In addition to the inhibition of arachidonic acid metabolism by COX inhibition, other possible mechanisms for the multiple effects of ASA include increased ROS production, alterations in mitochondrial function, cell signaling and induction of apoptosis [7], [19], [30], [31], [32], [33]

ROS generation was detected using a Leica fluorescence microscope (Leica DM6000B) and Leica LAS X software, and the quantitative analysis was performed with ImageJ