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Acknowledgements Y.C.A

People who have mutations in genes that are involved in homocysteine metabolism, such as MTHFR mutation rs1801133, are more likely to get a migraine [86]

ameliorating refers to any therapeutically beneficial result in the treatment of a disease state, e.g., an inflammatory disease state, including lessening in the severity or progression, remission, or cure thereof

This comprehension is supported by the concept Reactive Oxygen Species (ROS)-induced ROS-release (RIRR) in which the excessive ROS can collapse mitochondrial membrane that would lead to temporary increase in ROS generation by the electron transfer chain 32

Supplementary material The Supplementary material for this article can be found online at: References 1 AljayyoussiG.TyrerH

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