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Xie noted that saikosaponin A can dose-dependently decrease the expression of multi-drug resistant protein P-glycoprotein (P-GP) in the temporal cortex and hippocampus, thereby reducing the level of refractory epilepsy caused by pirocarbine (Yu et al., 2012

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Thus, degradation rates of 30 nmol g-1FW h-1would mean that some glutathione pools must turn over and be resynthesized within a few hours

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