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The pKa values of side-chain groups, including side-chain carboxyl and amino groups, depend on the groups chemical nature.The classification of an amino acid as acidic or basic depends on the pKa of the side chain as well as the chemical nature of the group

The interconnectedness of these molecular players underscores the challenge of targeting AD at the molecular level, requiring a multifaceted approach to disrupt these networks effectively

LbNOX catalyzes NADH oxidation to NAD using molecular oxygen (Figure 7B), thereby bypassing the mitochondrial ETC

In contrast, the transcriptomic analysis shows a downregulation of genes associated with glucose metabolism in both cortex and medulla in CKD

doi: 10.1016/j.suponc.2012.05.002 [PubMed] 25070601 Raffa RB, Haidery M, Huang HM, Kalladeen K, Lockstein DE, Ono H, Shope MJ, Sowunmi OA, Tran JK, Pergolizzi JV Jr

Inversely, it is not possible to discount a role for an enzyme on the basis of lack of induction