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Additionally, among SASP factors, there are growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1), which, when secreted into the environment by senescence cells, stimulate the repair and regeneration of surrounding tissues [13]

[DOI] [PubMed] [Google Scholar] 116.Wharton S, Batterham RL, Bhatta M, et al

For localised injuries, injecting as close to the affected tissue as practical can improve outcomes significantly compared to a distant injection site

The consequence of penetrating epithelial cells is the initiation of the ionization process where NSAIDs do not dissolve in fats, thus remaining present in these cells