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Nat Commun (2019) 10(1):4185

In this case, your healthcare provider will recommend supplementation to help get your level where it should be

In either case, energy is spent to detoxify ROS via NADPH and GSH instead of being used for other functions like, e.g., ATP synthesis

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This metabolic shift reduces central serotonin availability while increasing neuroactive kynurenine metabolites, such as quinolinic acid, which enhance glutamatergic neurotransmission and promote excitotoxicity