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HA and Gel can be degraded by hyaluronidase and gelatinase in damaged tissues, and they are often used as MN manufacturing materials to release multifunctional nanotherapeutics

doi: 10.1080/10715762.2017.1402303

Oral (research context): Animal studies showed oral activity at 500 mcg/kg, and AOD-9604 has GRAS status as a food ingredient

PMID 11140381

Collagen is also involved in other physiological processes, such as homeostasis and angiogenesis, and is also present in pathologies such as cancer, fibrosis, or atherosclerosis [59,60]