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In addition to the water-insoluble gum base, chewing gum preparations regularly contain a water-soluble component which is formed, for example, by softeners, sweeteners, fillers, flavours, flavour enhancers, emulsifiers, dyes, acidifiers, antioxidants and the like, with the proviso that the constituents have at least adequate solubility in water

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To explore the metabolome-metagenome interplay, correlation analyses between host metabolome and microbiome were performed

However, the "safety" of a supplement also depends on its purity and how well your body can actually use it

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doi:10.3389/fimmu.2020.01538