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In particular, the pro-inflammatory state observed during the aging process may provide a link between cytokine-induced CD38 expression, age-related tissue NAD decline, and the inflammaging theory [1, 53]

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Our findings revealed elevated plasma homocysteine levels in 37 (74%) RA patients on methotrexate and folic acid compared to only 27 (55%) patients on other therapies (Chi-square p-value 0.049) (Table 2)

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