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Surprisingly, we found elevated expression of these neuronal genes at day 30 (Fig 3B), suggestive of hyperinnervation, in response to the original injury

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as nutrient signals, to activate important pathways [mammalian target of rapamycin complex (mTORC) and autophagy]

It is a natural byproduct of cellular energy production, but if it is not managed, it can damage the structure of the cell over time