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These strategies may not prevent the development of tumor hypoxia due to the hyperactive oxygen metabolism prevalent in tumor cells, so it is particularly important to find ways to reduce oxygen consumption and thus alleviate the hypoxic microenvironment at its root [20]

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also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling

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Given their central regulatory roles, adipokine pathways represent attractive therapeutic targets for obesity-related disorders

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