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however, the use of mainly artificial assay systems makes interpretation difficult and few reports document direct pathogenic proteinenzyme interactions within a specific intact cell type

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11,78 Moreover, suppressing either component of system Xc induces ferroptosis by disturbing cystine uptake, then limiting GSH synthesis

In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells

The OCR was measured in real-time, quantifying the picomoles of oxygen consumed per minute (pmol/min), and graphed over time, before and after the addition of Rotenone to the culture medium (baseline OCR and specifically used for measuring mitochondrial respiration)

Funding This study was supported, in part, by research grants from Shenzhen Peacock Plan (No