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Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, et al

2-CDA + ARA-C is ineffective therapy for relapsed or refractory AML in adults

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To better understand the clinical utility of flavonoids and assess their potential as adjunctive therapies, the following areas need to be further investigated: structural optimization, drug targeting, and inhalation delivery systems, standardized research reporting, and multi-omics data integration, along with rigorous multicenter clinical trials and comprehensive safety evaluations

Proceedings of the National Academy of Sciences of the United States of America, 103 , 5762