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Similar to the partially purified enzymes from kiwifruit and thale cress, the recombinant enzyme is a homodimer with 70 kDa of molecular weight

Single-cell RT-qPCR in L5p neurons during P6P15 suggests that the decrease of DOBs depolarizing action cannot be fully explained by a reduction in 5-HT 2A expression, suggesting indirect mechanisms acting early in development (Bque et al., 2004)

KPV (Lys-Pro-Val)# Evidence Level: Preclinical (animal studies + in vitro) Research Status: Not FDA-approved

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However, its growing popularity as a skin-lightening supplement has encouraged many people to use it without fully understanding its limitations or potential risks

doi: 10.1021/mp3004622 227 VilladsenJ