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153 While there is mounting evidence that augmenting antidepressant therapy with atypical antipsychotics can increase treatment efficacy, these drugs add another layer of problematic side effects

Vaario LM, Fritze H, Spetz P, Heinonsalo J, Hanajik P, Pennanen T

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By inducing excessive oxidative stress, NPC1L1 inhibition increased treatment cytotoxicity and sharply decreased the number of persisters, whereas recovering the key substrates of NPC1L1, cholesterol, and vitamin E, markedly compromised lipotoxicity-mediated oxidative stress