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doi: 10.1136/bmj.h4183

Additionally, berberine, an alkaloid found in several plants including goldenseal and barberry, further supports SIRT1 activation through its ability to induce NAD + biosynthetic pathways and improve metabolic health 180

The analysis indicates that gut microbiota dysbiosis is not only a consequence of sepsis but also a key amplifier driving its pathological process

Addressing mechanistic uncertainties and translational barriers will be critical for harnessing its therapeutic potential and realizing effective interventions against some of the most challenging medical conditions (Table 4)