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In animal experiments, sunitinib, a VEGFR-2 inhibitor, completely inhibited pilocarpine-induced angiogenesis and seizures (72)

This process disrupts the antioxidant defense system and metabolic balance of gastric epithelial cells, thus promoting the carcinogenesis

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Whether this improved uptake is associated with better RNA protection, hence limiting their degradation, or the NPs physical and chemical properties influencing the RNAs internalization via endocytosis mechanisms is debatable (Zhang et al., 2022a)

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