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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

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"Circadian regulation of NNMT expression and its role in metabolic homeostasis." Journal of Biological Rhythms, 36(4), 342-356

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B12 deficiency is common in people who follow a vegetarian or vegan diet

Caution is warranted when using the peptide alongside other compounds, particularly those affecting metabolism or cardiovascular function