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Patients with homozygosity at this mutated locus tend to exhibit a more severe clinical phenotype, usually associated with severe mental retardation and early onset seizures, and five of them died early in life [6,7,8]

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This process damages the lung after repeated bouts of EIPH. Dr

Low body temperature (hypothermia) is also a warning, as it reflects severe impairment of the body's ability to regulate temperature

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InterpretationAcross domains, most findings are preclinical