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185 Pyruvate metabolism dysfunction in cancer cachexia involves multiple enzymes, such as PDH, PDK and pyruvate carboxylase, which affect metabolite levels along the metabolic axis and orchestrate critical processes in myogenic differentiation and muscle proteolysis

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Subjects underwent semen analysis at baseline and 3-months after therapy with semen being obtained by masturbation after a sexual abstinence of 3-5 days