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doi: 10.3892/etm.2015.2964 74

Table 2 Clinical trial analysis of past melanocortin agonists

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The peptide activates melanocortin-4 receptors in the hypothalamus and melanocortin-3 receptors in limbic circuits, triggering dopamine release and nitric oxide synthesis in arousal pathways

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In neurodegenerative diseases such as AD and PD, abnormalities in energy metabolism result in insufficient glucose uptake and mitochondrial dysfunction, leading to inadequate energy supply and oxidative stress