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In contrast, CRISPR/Cas9 knockout of Drp1 has high specificity and basic research value, making it suitable for diseases that require long-term gene regulation

However, the issues of drug resistance and drug safety that may emerge from the combined treatment of c-MET inhibitors and ICIs for tumors cannot be ignored either

Following treatment and subsequent remission in patients, relapse of the disease is driven by this drug-resistant CD34 + CD38 - LSC fraction which has unlimited self-renewal capabilities (102)