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69 , 79 , 80 In some cases, nodular regenerative hyperplasia and steatosis have been observed

However, sensor polypeptides specific to H2O2 and other ROS are still to be identified and little is known about early effects on biological macromolecules regulating ROS-induced cellular effects

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Regulatory agencies should establish guidelines for GPS-based pharmaceuticals, including specifications for purity, stability, and impurity limits (EFSA Panel on Additives and Products or Substances used in Animal Feed, 2023