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If tests are negative or not feasible to perform, but suspicion remains, consider HLA-DQ genotyping to assess genetic susceptibility and to support long term decision making for first degree relatives

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Handling & Preparation Reconstitute using bacteriostatic water per laboratory protocol Use only trained professionals Follow institutional research and safety standards Storage Instructions To preserve potency and stability: Store lyophilized vials in a cool, dry environment Refrigerate reconstituted solutions at 28C Protect from heat, light, and moisture Avoid repeated freezethaw cycles Possible Observations in Research Settings Reported observations may include: Mild redness at administration site Temporary dizziness or headache Transient nausea All findings should be documented and evaluated within controlled research environments

Human tolerance development remains understudied

doi: 10.1038/nrdp.2017.40 [11] Wang H, Li L, Qin LL et al

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