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Among these choices is the question of supplementation, particularly as it pertains to antioxidants like glutathione

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However, key challenges remain: optimizing metabolite-specific delivery systems to avoid systemic immune disruption, defining quantitative thresholds for beneficial versus immunosuppressive concentrations in human tumors, and resolving discordant preclinical-clinical findings as exemplified by the IDO1 inhibition failure in ECHO-301

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