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If more is needed, increase to 8 units, 5x/week Administration Subcutaneous Timing About 60 minutes before bed Vial Size 5mg Reconstitution 2mL Bacteriostatic Water Cycle Length 8 weeks on, 8 weeks off Vials / Month 1 Vials / Cycle 1 DSIP calms the stress system helping normalize nighttime cortisol signaling

Bruscia, E.M

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The proposed condensation domain C* (CesA_C2) 8 transfers the hydroxy group of D- O -Leu-D-Ala- S -PCP to the thioester carbon of L- O -Val-L-Val- S -PCP to form an ester bond resulting in the PCP-bound tetradepsipeptide L- O -Val-L-Val-D- O -Leu-D-Ala- S -PCP ( DP4 ) 24 , which is subsequently transferred to the serine hydroxy group of the CesB C-terminal TE domain (Fig

2C and Supplementary Table 1)

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