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Glutathione and glutaredoxinkey players in cellular redox homeostasis and signaling

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub

European Review for Medical and Pharmacological Sciences, 15 (5), 509514

The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

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Proc Natl Acad Sci U S A (2009) 106(29):119138.10.1073/pnas.0812138106 39 BakerM