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The deletion of PNPLA2 in adipocytes resulted in reduced PPAR activity and expression of target genes, including lower UCP1 protein levels and when exposed to cold, mice were cold sensitive (140)

The rate of infusion for the second dose may range from 15 minutes (for patients in extremis) to two hours, as clinically indicated

Oral formulations: Investigated in capsule form, though bioavailability and efficacy are less well established

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