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The frequent reliance on multidrug treatment strategies highlights the limited understanding of ASD pathophysiology and is based on the limited efficacy of currently available pharmacological therapies

Documenting pain levels during specific activities reveals patterns and guides activity modification decisions

A phase 1 trial in healthy volunteers showed promising tolerability and dose-dependent methionine reduction (84)

On the other hand, the expression of various male reproductive genes, such as testis-related transcription factors (Sox9a and wt1), was suppressed by endosulfan (Rajakumar et al., 2012), while BPA is nonsteroidal with binding affinity for estrogen receptors, ER and Er (Welshons et al., 2003)

In contrast, in diabetic dogs treated with an aldose reductase inhibitor, the diabetes-induced defect in nerve conduction velocity was prevented

doi:10.1136/fn.81.2.F130 [61] R