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Since mRNA is not very stable, these constructs include modified nucleosides to prevent degradation

A.Martins MdeL.ChanK

Similarly, the concentrations of Glu were monitored in phloem cells of broad bean (7.4 mM), alfalfa (12.7 mM), red clover (13.8 mM) (Sandstrom and Pettersson, 1994), while 1 mM in leaf apoplasts of spinach (Lohaus and Heldt, 1997) and Arabidopsis (Toyota et al., 2018)

doi: 10.3389/fimmu.2018.00268 Received 21 November 2017 Accepted 30 January 2018 Published 19 February 2018 Volume 9 - 2018 Edited by Tobias Schuerholz, Universittsmedizin Rostock, Germany Reviewed by Sergio Ivn Valds-Ferrer, Instituto Nacional de Ciencias Mdicas y Nutricin Salvador Zubirn, Mexico

Conversely, highly hydrophobic linkers may promote aggregation and rapid systemic clearance [20, 77]

PMID: 20534738