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(2012) reported that SAMP8 fast-aging mice presented significant amounts of IL6- and TNF- in their cochlea after only 1 month, whereas R-line fast-aging resistant mice displayed this phenomenon only after 1218 months

The AMPK-mediated response mitigates mitochondrial stress, promotes mitochondrial biogenesis, facilitates mitophagic clearance of irreversibly damaged mitochondria, enhances glucose uptake, and supports anaerobic glycolysis as an alternative ATP source [200,201,202,203,204]

Biol Blood Marrow Transplant 24(8):15461553 Chang B et al (2016) SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma