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Notably, the repression of lipogenic gene and protein expression and the decreased serum triglyceride levels seen in Gclc L-KO mice were reversed in L-DKO mice (Fig

Instead, Weigand and Egenolf [76] have shown that moderate zinc deficiency did not alter lipid concentration and fatty acid composition in the liver of rats fed a high-fat diet

We and others have observed that enhanced de novo synthesis of serine and glycine from glucose reduces the reliance of cells on extracellular sources [43, 99]