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Accordingly, these findings show the beneficial effect of crude HEM in promoting OL maturation and myelination in the white matter of developing brains

However, curcumin administration demonstrated effectively counteracted retinal degeneration, preventing alterations in the apoptotic cascade, MAPK, and small ubiquitin-like modifier 1 (SUMO-1) pathways, this therapeutic intervention preserved RGC viability and maintained normal histological architecture by stabilizing critical protein degradation mechanisms [42]

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[The Working Group noted that the latter study was limited by the lack of quantitative or semiquantitative evaluation.] After a 24-hour at 320 g/mL (IC 25 ) or 480 g/mL (IC 50 ), aspartame induced phosphorylation of histone H2AX (H2AX), a biomarker of DNA double-strand breaks, in HepG2 (human hepatoblastoma) cells (Qu et al., 2019)

Furthermore, Dean et al