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Clinical data shows that starting at 2mg instead of 4mg significantly reduces GI symptom frequency and intensity

Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress

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Almost none mention the finding that matters most for formulators

It is noted that, in mammals without chronic diseases, such as HIV infection, diabetes, etc, which might impair physiologic GSH metabolism, a strategy for the pharmaceutical administration of other antioxidants which improve GSH metabolism or compounds which are themselves appropriate antioxidants may be employed

Nature 560 , 360364 (2018)