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Available from: [DOI] [PubMed] 149.Landovitz RJ, Donnell D, Clement ME, Hanscom B, Cottle L, Coelho L et al

doi: 10.1172/JCI65859

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Key Functions of IGF-1 Stimulates protein synthesis in muscle tissue Promotes cell division (mitogenesis) Inhibits cell death (anti-apoptotic) Activates satellite cells - the stem cells of muscle Enhances nutrient uptake in muscle fibers Supports bone growth and density Promotes nerve tissue repair The Limitation of Native IGF-1 Despite its powerful effects, native IGF-1 has a significant limitation for research applications: extremely short half-life