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doi: 10.1007/s11157-022-09637-w 147 Lpez-BentezA.Guevara-LaraA.Domnguez-CrespoM

A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

Br J Pharmacol (2010) 160(3):46779

doi: 10.1016/j.eng.2020.09.016 61 ZhouQ.GuR.LiP.LuY.GuQ

Unlike systemic immunotherapies that are limited by toxicity and off-target effects, injectable or implantable hydrogels can provide localized, sustained, and precisely dosed delivery of immune modulators [61]

His book presents an extended discourse on the empirical and scientific foundation for his treatment regimen and an expansive description of the treatment and diet followed by 50 patients selected from 30 years of clinical practice