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However, avoid using GHK-Cu at the same time as highly acidic products (like low-pH Vitamin C or AHAs), as acids can break the bond between the peptide and the copper ion, making it less effective

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doi: 10.3389/fphar.2025.1524654 Received 08 November 2024 Accepted 29 April 2025 Published 14 May 2025 Volume 16 - 2025 Edited by Hua Li, Air Force Medical University, China Reviewed by Xie-an Yu, Shenzhen Institute For Drug Control, China Bing Yu, Second Military Medical University, China Updates Copyright 2025 Ma, Chu, Quan, Li, Zhou, Han, Li, Pan, Wang, Yan, Shu and Qiao

Children who have difficulty converting EFAs to long chain fatty acids can obtain a preformed source of EPA and DHA as a nutritional supplement or in the diet by consuming fish or fish oil

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The reasoning strongly suggests no clinically significant pharmacokinetic interaction, but pharmacodynamic nuances related to GH-axis stimulation remain incompletely characterized