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4 Ferroptosis defense systems 4.1 SLC7A11-GSH-GPX4 axis The main barrier that inhibits the path of ferroptosis is the redox of the cell, which is that it can instantly remove membrane phospholipid peroxide

Conclusions and future perspective Despite a large part of literature exploring on the accumulation and the origin of ROS, current antioxidant-based therapies lack of specificity for dysfunctional tissues, cells, and organelles, and thus may not reach an effective concentration at the target site of pathologic oxidative stress

The observations demonstrated that baicalin enhanced glucose disposal by increasing GS activity, potentially due to upregulated GS expression instead of direct activation by baicalin

Winkelstein JA: Chronic granulomatous disease

A review of glioblastoma immunotherapy

[111] used bilateral ovariectomy to construct an osteoporosis model and then administered baicalein by gavage for treatment