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Sierra, L., Roco, J., Alarcon, G., Medina, M., Van Nieuwenhove, C., de Bruno, M

In addition, the increase in micronucleus frequency occurred earlier (at 24 hours) in the peripheral blood than in the bone marrow, whereas, physiologically, changes in peripheral blood micronuclei ratios would be expected to be detected 1224 hours later than changes in the bone marrow.] Several micronucleus assays, performed in accordance with GLP, gave negative results

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5c), indicated significant reductions in key genes of the NF-B and TNF signalling pathways in livers from mice overexpressing AGXT, including Nfkb2 , Relb and Tnf as well as chemokine (CC motif) ligand 2 ( Ccl2 ) and Ccl5 that are known as drivers and therapeutic targets in MASH together with Ccr2 that regulate the recruitment of monocyte-derived cells in MASH 48