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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Furthermore, it has been demonstrated that TNFalfa and IFNgamma are both elevated in the mucosa of IBD patients and they induce changes in epithelial paracellular permeability, associating with tight junction protein restructuring (104)