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Endothelial dysfunction is induced by the detrimental actions of high glucose levels and increased oxidative stress on endothelial cells that make up the vascular lining

10.1021/acs.biomac.4c00389 128 TengY.ChiJ.HuangJ.LiZ.LiS.WuX.et al (2025)

Intestinal permeability and the propagation of acute graft-versus-host disease GVHD is a systemic complication that occurs following allogeneic hematopoietic stem cell transplant

Results: After excluding 2 cases with unreliable VCTE measurements, VCTE and MRE identified the following stage distributions: F0-F1 (n=32 vs 69), F2 (n=20 vs 9), F3 (n=15 vs 14), and F4 (n=36 vs 11) with statistically significant differences in distribution for F0-1 (p value 11.2), LSM ( 15 kPa), FIB-4 ( 2.67), and histology (F2, F3, F4) to assess the risk of occurrence of the primary outcome

Think of them as smaller, more targeted cousins of proteins

Pharmacological targeting of RAS: recent success with direct inhibitors