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Q4W=every 4 weeks

Only 3.3% of patients on the higher dose stopped treatment because of GI-related side effects

It demands the same level of focus and sterile discipline as any other part of your experiment

most patients report no downtime and can resume normal activity immediately

In this study, mice were given equivalent quantities of cuprizone regardless of feed formulation, and feed was replenished in line with standard protocols 34,39 , therefore it is likely that the observed differences between formulations is due to differences in consumption of the feed between different formulations

Polomsky M, Siddall KA, Salvador R, Dubecz A, Donahue LA, Raymond D, et al