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Bu genel ynelimin rasyonel nedeni, l-karnitin hzl emilim oran ile ya transportasyon dzeyi, kas ars minimizasyonu ve toparlanma sreleri optimizasyonudur ( 7 , 8 , 9 )

Endothelial dysregulation and proliferation in the intima, smooth muscle cell proliferation and resistance to apoptosis in the medial layer, and adventitial fibroblast activation collectively contribute to the narrowing of the vascular lumen, thus causing PH (Nie et al., 2020

Nature Communications (2020)

10.1001/jama.2008.862 JAMA

Activation of MC1R stimulates adenylyl cyclase through G-protein coupling, increasing intracellular cAMP levels

Lancet 381 , 557564 (2013)