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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes

The kidney is considered to be the main source for the GPx3 in plasma, which is primarily synthesized in the kidney proximal tubular cells 2,3

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Prevalence of CKD increases with age, affecting approximately 40% of cats greater than 10 years of age and 80% of cats greater than 15 years of age