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The pharmacokinetic and toxicity properties of the lead compounds (CB-27, CB-41, CB-50, CB-53, CB-58, CB-59, and CB-61) were compared to CQ (Supplementary Table S6)

These samples assisted in identifying baseline FOXO4 expression patterns and age-related changes in Leydig cells, with all procedures strictly adhering to ethical guidelines and informed consent protocols [2]

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